ACS Catalysis7 7 Journal of the American Chemical Society17 Organic Letters15 4 Anne-Elisabeth Gies and, Michel Pfeffer.
However, this reaction needs two equivalents of Grignard reagent, since one equivalent is "sacrificed" as a hydrogen acceptor. Jump to Scheme 4 Based on the above experimental results and the use of norbornadiene in Catellani reactions followed by retro-Diels—Alder reaction firstly reported by Lautens et al.
The combined organic phase was washed with brine, dried with anhydrous Na2SO4, filtered, and concentrated under reduced pressure.
DOI: The Journal of Organic Chemistry75 14 Synlett29, — Doty, Qingping Tian, and, John M. The Journal of Organic Chemistry73 2 Journal of the American Chemical Society49 The reaction tolerates a variety of substituents at the alkyne and at the biaryl species and proceeds in moderate to good yields.